Drug injection Description, find Lowest Prices on, depo-Provera (medroxyprogesterone acetate) Injectable Suspension, USP. Continue typing to provera refine. The birth injection control shot (sometimes called Depo-Provera, the depo Depo shot, or provera dmpa) contains the hormone progestin. Sking of depo provera calendar provera Climacteric The age of provera the patient constitutes no absolute limiting factor although treatment with progestin may depo mask the onset of the climacteric. The dosage used may be depo important in minimizing these adverse effects. Legal Category, pOM: Prescription only medicine. Call your doctor at once if you provera have: menstrual periods that provera are heavier or longer than normal; severe pain provera in your lower stomach; swelling in your face, or your hands, ankles, and injection feet; pain, bleeding, oozing (pus or skin changes. How Effective Is It? Decrease In Bone Mineral Density Studies in pre-menopausal women show that medroxyprogesterone provera acetate given as 150 mg intramuscularly every three months reduces serum estrogen levels depo provera and is depo provera calendar associated with loss of bone provera mineral density (BMD). It provides long-term protection as long as you get the shot every 3 months. It's a provera shot that a doctor gives you in the arm or buttocks. Prolonged Use The effect of prolonged use of depo-provera Sterile Aqueous Suspension at the recommended doses on pituitary, ovarian, adrenal, hepatic, and uterine function is not depo provera known. There are two fees associated with the use of the birth control injections: the doctors visit the quarterly injections Office visits to obtain your prescription and the birth control injections range from 50 to 200; follow up visits for depo additional injections are usually between 20. Depo-Provera injection is a prescription and the injection provera is obtained from your healthcare provider every 11 to 13 weeks. If you have the injection during the first 5 days of your menstrual cycle, you'll be immediately protected against becoming pregnant. Your health care provider will clean the injection site with an alcohol pad. Common Depo-Provera side effects may include: changes in your menstrual periods; swelling, weight gain; headache; or lumps or dimpling in your skin where injections were given. How it works, the contraceptive injection steadily releases the hormone progestogen into your bloodstream, which prevents the release of an egg each month (ovulation). What Are the Side Effects? You should consume foods that are rich in vitamin D and calcium (or take supplements) while taking Depo-Provera to lower the risk depo of calcium bone injection loss. Seek emergency medical attention or call the Poison Help line. You might not become pregnant for some time after depo your last injection of Depo-Provera. Depo-Provera isn't appropriate provera for everyone, however. It can take up to 1 year for your fertility to return to normal after the injection wears off, so it may not be suitable if you want to have a baby in the near future. To ensure provera you're not pregnant when you're injected injection with Depo-Provera, your health care provider will likely do your first injection within seven days of the start of your period. There is evidence that women prescribed Depo-Provera in the immediate puerperium can experience prolonged and heavy injection bleeding. Pregnancies have occurred as early as 14 weeks after a preceding injection, however, in clinical trials, the mean time to return of ovulation was.3 months following the preceding injection. Brand Names: Depo-Provera, depo-subQ injection provera 104, medically reviewed depo on Aug 13, 2018, what is Depo-Provera? It is unknown if use of Depo-Provera by younger women will reduce peak bone mass and increase injection the risk for fracture in later life. Women should be counselled that Depo-Provera does not protect against sexually transmitted infections (STIs) including HIV infection (aids). Medroxyprogesterone acetate may have cortisol -like glucocorticoid activity and provide negative feedback to the hypothalamus or pituitary. Serum accumulation over time was not demonstrated. The chemical name for medroxyprogesterone acetate is Pregn-4-ene-3, 20-dione, 17(acetyloxy)-6-methyl-, (6). The structural formula is: Depo-Provera for intramuscular injection is available as 400 mg/mL medroxyprogesterone acetate. Pregnancy and Depo-Provera Depo-Provera may harm an unborn baby. Progestin stops you from getting pregnant by preventing ovulation. 4.8 Undesirable effects The table below provides a listing of adverse drug reactions with frequency based on all-causality data from clinical studies that enrolled more than 4200 women who received injection dmpa for contraception for up to 7 years. F) provera Sulfobromophthalein and other liver function test values may be increased. Your cycle will probably return to normal after you stop using this medicine. Multi-Dose Use Multi-dose use of depo-provera Sterile Aqueous Suspension from a single vial requires special care to avoid contamination. View All, depo-Provera Description, depo-Provera Sterile Aqueous Suspension contains medroxyprogesterone acetate, which is a derivative of progesterone and is active by the parenteral and oral routes of administration. Pharmaceutical particulars.1 List of excipients Methylparaben (E218) Macrogol 3350 Polysorbate 80 Propylparaben (E216) Sodium chloride Hydrochloric acid Sodium hydroxide Water for injections.2 Incompatibilities Not applicable. G) The effects of medroxyprogesterone acetate on lipid metabolism are inconsistent. 4.6 Fertility, pregnancy and lactation Doctors should check that patients are not pregnant before initial injection of Depo-Provera, and also if administration of any subsequent injection is delayed beyond 89 days (12 weeks and five days). Since loss of bone mineral density (BMD) may occur in females of all ages who use Depo-Provera injection long-term (see section.4 a risk/benefit assessment, which also takes into consideration the decrease in BMD that occurs provera during pregnancy and/or lactation. Though no formal drug interaction trials have been injection conducted, concomitant administration of strong CYP3A inhibitors is expected to increase concentrations of medroxyprogesterone acetate, whereas the concomitant administration of strong CYP3A inducers is expected to decrease medroxyprogesterone acetate concentrations. A form of this medication may also be used to treat endometriosis (a condition where tissue that lines provera the uterus grows in other areas of the body). Each mL of the 400 mg/mL suspension contains: Medroxyprogesterone acetate 400 mg, polyethylene glycol 3350.3. To get the shots full birth control powers, you have to remember to get a new shot every 12-13 weeks. You should not use the injections if you think depo provera side effects you are pregnant; consult your physician about using Depo-Provera while breastfeeding. Precautions precautions Physical Examination It is good medical practice for all women to have annual history and physical examinations, including women using depo-provera Sterile Aqueous Suspension. But injection you also may be able to get shots at the health center to bring home and give yourself.. Can I Get Pregnant After I Stop Using Depo-Provera? By contrast, in women using dmpa, the fracture risk before and after starting dmpa was not increased (relative risk.08, 95.92-1.26). The contraceptive injection (Depo-Provera, Sayana Press or Noristerat) releases the hormone progestogen into your bloodstream to prevent pregnancy. Description, dEPO-provera Sterile Aqueous Suspension contains medroxyprogesterone acetate, which is a derivative of progesterone and is active by the parenteral and oral routes of administration. The effects of medroxyprogesterone acetate on lipid metabolism have been studied injection with no clear impact demonstrated. Also use a condom every time you have vaginal sex. Its 99 effective in preventing pregnancy. You can become pregnant as soon as 3 to 4 months after your last shot. You need to stop taking Depo-Provera several months ahead of time if you plan to become pregnant. The chemical name for medroxyprogesterone acetate is Pregn-4-ene-3, 20-dione, 17-(acetyloxy)-6-methyl-, (6). What are the side effects or health risks of Depo-Provera? Medroxyprogesterone acetate should be given to a pregnant woman only if clearly needed. The following laboratory tests may be affected by progestins including Depo-Provera Sterile Aqueous Suspension: a) Plasma and urinary injection steroid levels are decreased (e.g. Both increases and decreases in total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol depo have been observed in studies. Tell your doctor right away if you become pregnant, or if you plan to become pregnant soon after you stop using Depo-Provera. Depo-Provera is contraindicated as a contraceptive at the above dosage in known or suspected hormone-dependent malignancy of breast injection or genital organs. Your health care provider might discourage use of Depo-Provera if you have: Unexplained vaginal bleeding, breast cancer, liver disease, sensitivity to any component of Depo-Provera. Sulfobromophthalein and other liver function test values may be increased. Qualitative and quantitative composition, each ml of suspension contains 150 mg medroxyprogesterone acetate. View medicine changes To view the changes to a medicine you must sign up and log. What Are the Advantages of Depo-Provera? Depo-Provera will not protect you from sexually transmitted diseases - including HIV and aids. You can start using the birth control shot whenever you want. Medication Guide patient information No depo information provided. Investigations change in weight (increase or decrease) Hepatobiliary Disorders cholestatic jaundice, including neonatal jaundice Skin provera and Subcutaneous Tissue Disorders skin sensitivity reactions consisting of urticaria, pruritus, edema and generalized rash acne, alopecia and hirsutism rash (allergic) with and without pruritis Immune. You're more likely to have heavy and irregular bleeding if you have the injection during the first few weeks after giving birth. Further provera doses: These should be given at 12 week intervals, however, as long as the injection is given no later than five days after this time, no additional contraceptive measures (e.g. Revised: Apr 2017 Side Effects side effects See precautions for possible adverse effects on the fetus Reproductive System And Breast Disorders Nervous System Disorders Psychiatric provera Disorders nervousness euphoria mental depression insomnia General Disorders And Administration Site Conditions edema pyrexia fatigue malaise. Possible number of additional cases of breast cancer diagnosed up to 10 years after stopping injectable progestogens* provera Age at last use of dmpa No of cases per 10,000 women who are never-users Possible additional cases per 10,000. Post Partum: To increase assurance that the patient is not pregnant at the time of first administration, this injection should be given within 5 days post depo partum if not breast-feeding. Depo-Provera will not be effective in preventing pregnancy if you do not receive an injection every 3 months. Women with a strong family history of breast cancer should be monitored with particular care. Progesterone, estradiol, pregnanediol, testosterone, cortisol). Marketing authorisation number(s) PL 00057/0965. Ethical Consideration, how do you use Depo-Provera? So you have to make an appointment at a health center, and then remember to go to the appointment. In adolescents, Depo-Provera may be used, but only after other methods of contraception have been discussed provera with the patient and considered unsuitable or unacceptable. Hepatic Impairment depo-provera Sterile Aqueous Suspension should not be used by women with significant liver disease and should be discontinued if jaundice or disturbances of liver function occur see precautions. 6.6 Special precautions for disposal and other handling No special requirements for disposal. This version is called Depo-SubQ Provera 104. Therefore, coadministration with strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, atazanavir, indinavir, injection nefazodone, nelfinavir, ritonavir, injection saquinavir, telithromycin, voriconazole) or strong CYP3A inducers (e.g., phenytoin, carbamazepine, rifampin, rifabutin, rifapentin, phenobarbital,. The following laboratory tests may be affected by progestins including depoprovera Sterile Aqueous Suspension: Plasma and urinary steroid levels are decreased (e.g. Schedule your next injection. Depo-Provera injections should be given every 3 months. Tell your doctor if you have ever had: light or irregular menstrual periods; risk factors for osteoporosis (such as low bone mineral density, a family history of osteoporosis, drinking large amounts of alcohol, or if you smoke a breast. The physical examination, however, may be deferred until after initiation of Depo-Provera if requested depo by the woman and judged appropriate by the clinician. A longer duration of treatment was associated with a slower rate of BMD recovery. Indications Dosage, indications, adjunctive therapy and palliative treatment of inoperable, recurrent, provera and metastatic endometrial or renal carcinoma. Medroxyprogesterone acetate was not mutagenic in a battery of in vitro or in vivo genetic toxicity assays. Immediately after injection of 150 mg/ml MPA, plasma levels were.7.3 nmol/l. Mean percent changes in BMD in the Depo-Provera group are listed in Table. Decrease in Bone Mineral Density Studies in pre-menopausal women show that medroxyprogesterone acetate given as 150 mg intramuscularly every three months reduces serum estrogen levels and is associated with loss of bone mineral density (BMD). Medical Disclaimer Next Side Effects Add to My Med List More about Depo-Provera (medroxyprogesterone) Consumer resources Professional resources Other Formulations Related treatment guides. Does the shot protect against STDs?
But it may not be suitable if you: think you effects might be pregnant don't want your periods to change want to have a baby in side the next year have unexplained bleeding in between periods or after sex have arterial. Talk to your doctor about these risks. Org: "Depo-Provera: An Injectable Contraceptive. Depo-Provera is depo effective at effects preventing pregnancy, but it doesn't protect you from sexually transmitted diseases. You can depo use our birth control app to keep track of your next shot day and set reminders for upcoming appointments. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Depo-Provera is 99 percent effective at preventing pregnancy. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Rash, swelling Of The Abdomen, visible Water Retention, rARE side effects. Mood changes, weight changes, delayed return to fertility (up to 6-10 months). Most women provera can have a contraceptive injection. You should consume foods that are rich in vitamin D and calcium (or take supplements) while taking Depo-Provera to lower the risk of calcium bone loss. If you decide that you want to get pregnant right away after you stop getting the shot, you should know the shot may delay your ability to get pregnant by up to 10 months. It can be useful for women who effects can't use contraception that contains oestrogen. Depo Provera contains a black box warning about the possibility of progressive bone loss. The contraceptive injection (Depo-Provera, Sayana Press or Noristerat) releases the hormone progestogen into your bloodstream to prevent pregnancy. As a progestin-only contraceptive, it may be a great choice if you are unable to use estrogen-based contraception. According to the manufacturer, if Depo Provera is used continuously for more than two years, the loss of calcium may significantly increase the risk of osteoporosis and broken bones. This may be easy for some people and harder for others, but the shot only works if you get it on time. If any of these effects effects persist or worsen, tell your doctor or pharmacist promptly. Decreased Calcification Or Density Of Bone. Tell your doctor if you wish to become pregnant in the near future. And Depo-Provera Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. Depo-Provera Warnings, provera depo-Provera may decrease the amount of calcium in your bones. If used correctly, the contraceptive injection is more than 99 effective. If you decide to get pregnant, you would likely have to wait for at least nine to 10 months before trying. Many women, in fact, are willing to tolerate the initial bleeding in exchange for the chance of not having to have a period anymore. Common side effects of Depo-Provera include: changes in menstrual periods, weight gain, nausea, stomach cramping or pain, bloating, dizziness, headache, tiredness, drowsiness, irritability, breast tenderness, decrease in breast size, acne, hair loss, decreased sex drive, hot flashes, joint side pain, or injection. Once stopped, it may take up to a year to regain fertility and start ovulating normally again. . Sometimes the doctor may recommend that you stop after 2 years so there's no effects long-term provera effect on your bones. There is also evidence suggestive provera of an association with neuro- ocular lesions,.g. Some women will report depo mild pain associated with the injection, while six percent will experience skin reactions around the area where the shot was delivered. After a miscarriage or abortion, you can have the injection immediately after a miscarriage or an abortion and will be protected against pregnancy straight away. Other possible side effects of the shot include: nausea weight gain headaches breast tenderness depression slight bruising where the shot was given very rarely, a small, permanent dent in the skin where the shot was given.
If examination reveals papilledema or retinal vascular lesions, medication should be withdrawn. The shot initial injection is given within the first five days of your menstrual bleeding. Caution should be exercised when medroxyprogesterone acetate is administered to shot a nursing woman. In these conditions oral therapy is recommended. See laboratory test interactions. Medroxyprogesterone acetate should be given to a pregnant woman only if clearly shot needed. After stopping Depo-Provera, it might shot take 10 months or more before you begin ovulating again. Decreases menstrual cramps and pain, lessens menstrual blood flow, and in some cases stops menstruation. To get the shots full birth control provera powers, you have to remember to get a new shot every 12-13 weeks. Because progestational drugs may cause some degree of fluid shot retention, conditions which might be influenced by this condition, such as epilepsy, migraine, asthma, cardiac or renal dysfunction, require careful observation. There are possible risks which may be associated with the inclusion of progestin in estrogen replacement regimen, including adverse effects on carbohydrate and lipid metabolism. Effectiveness Depo-Provera is 97 percent.7 percent effective. What are the pros and cons for depo Depo-Provera? When multi-dose vials are used, special care to prevent contamination of the contents is essential see warnings and precautions. Hepatic Dysfunction Monitor patients for hepatic dysfunction periodically and temporarily interrupt Depo-Provera Sterile Aqueous Suspension use if the patient develops hepatic dysfunction. It is important shot that you discuss your complete medical history with your doctor before receiving a Depo Provera injection. This may result in decreased plasma cortisol levels, decreased cortisol secretion, and low plasma acth levels. Actions, medroxyprogesterone acetate, administered parenterally in the recommended doses to women with adequate endogenous estrogen, transforms proliferative endometrium into secretory endometrium. It is a white to off-white, odorless crystalline powder, stable in air, melting between 200 and 210. Ovulation usually returns provera within 3 to 6 months for most women; however it is possible that you may not have your cycle for 12 to 18 months after discontinuing the injections. It also provides immediate pregnancy protection. Your health care provider will depo clean the injection site with an alcohol pad. This loss might be especially concerning in teens who haven't reached their depo peak bone mass. Because of this, the Food and Drug Administration added strong warnings to the injection packaging cautioning that Depo-Provera and Depo-SubQ Provera 104 shouldn't be used for longer than two years. Ethical Consideration, how do you use Depo-Provera? Progestin stops you from getting pregnant by preventing ovulation. T3 uptake values may decrease. After your first shot, its all about remembering when to get your follow-up shots. Physical Examination, it is good medical practice for all women to have annual history and physical examinations, including women using Depo-Provera Sterile Aqueous Suspension. Endometrial Carcinoma This product has depo been used primarily in post-menopausal women for the treatment of endometrial carcinoma. Add provera it to whatever calendar you use on a daily basis. Depo-Provera has a black box provera warning about possible bone loss: "Women who use Depo-Provera may lose significant bone mineral density (BMD).". Risk factors for osteoporosis, a history of depression, a history of heart attack or stroke. The mechanism of this decrease is obscure. Backup birth control isn't necessary after subsequent injections as long as they're given on schedule. Risks, in a year of typical use, an estimated 6 out of 100 women using Depo-Provera will get pregnant. You must have a shot four times a year (every 11 to 13 weeks) to maintain Depo-Proveras high effectiveness rate. Although initially sterile, any multi-dose use of vials may lead to contamination unless strict aseptic technique is observed. Because it has a lower dose of progestin, it may lead to fewer progestin-related side effects. Does the shot protect against STDs? Effects on the Hypothalmic-Pituitary-Adrenal Axis provera Some patients receiving medroxyprogesterone acetate may exhibit suppressed adrenal function.